A role for sex chromosome complement in Oxford

Xu, A. IL regulates murine lupus. Koch, P. Abstract Most autoimmune diseases are more common in women than in men. John ed. Paris— b. Graphs show mean clinical score for each group at each time point.

Further, although late stages of murine lupus characterized by renal fibrosis have been considered a Th2-mediated disease 29initiation of events in the early phase of disease have been reduced by treatment with Th2 cytokines such as IL-4 and 30 — Yin, Z. Reprints and Permissions.

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Burgoyne, A. Rissman, R. However, effects of sex hormones do not rule out a more direct effect of sex chromosomes. Witek, J. Lee, and R. In contrast, our experimental murine system offers distinct advantages for investigating direct effects of X and Y genes.

Mice were injected i.

  • Chromosomes are long segments of genes that carry hereditary information. They are composed of DNA and proteins and are located within the nucleus of our cells.
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A role for sex chromosome complement in Oxford

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  • May 12,  · XX sex chromosome complement confers greater susceptibility to EAE. We addressed the role of the sex chromosome complement in the sex difference in EAE using the SJL strain because this strain had previously been shown to demonstrate greater disease susceptibility in females as compared with males ().We backcrossed the Sry-deficient Y chromosome from original outbred MF1 Cited by: Apr 28,  · To determine if the sex chromosome effect in active EAE was caused by the influence of the sex chromosome complement on the immune response, we adoptively transferred autoantigen-stimulated LN cells (LNCs) from ovariectomized XX or XY − Cited by:
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  • To begin to dissect the role of sex chromosome complement vs. sex hormones in this sexually dimorphic immune response, we used intact mice, ovariectomized. Oxford University Press X and Y Chromosome Complement Influence Adiposity and Metabolism in Mice The results reveal a role for the Y chromosome in metabolism independent of testes and gonadal hormones and.
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  • Mice of the XX sex chromosome complement, as compared with XY, demonstrated greater susceptibility to both EAE and lupus. This is the first evidence that the. The relative impact of sex chromosome complement versus gonadal sex on behaviour has been assessed [10][11][12], but also on non-behavioural traits such as metabolism or brain function 13, . Oxford: Academic Press; pp.
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  • Sex differences in coronary heart disease have been attributed to sex hormones, whereas the potential role of the sex chromosomes has been. The ideal experiment to test the role of sex chromosome genes in sexual Because the two sides of the brain differed in the complement of sex.
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  • Males and females exhibit several differences in brain structure and function. XY sex chromosome complement, allowing the decoupling of sex chromosomes​. In contrast, no sex chromosome effects were found on heart rate, body weight, or plasma To determine the role of the sex chromosome complement, we gonadectomized (GDX) the FCG at 6 Oxford University Press;
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