Our estimates of heritability are smaller than in previous studies of twins and siblings, both for cardiovascular traits [ 3738 ] and for personality traits [ 39 — 43 ]. Download citation. Adenylosuccinate lyase ADSL and infantile autism: absence of previously reported point mutation.
For 26 traits, a model in which only the environmental variance differed between young and old was selected, and for 20 of these traits, environmental variance was greater among older individuals so that heritability was lower.
Testing and reporting ACMG cystic fibrosis mutation panel results. In our cohort, four of five components of the five-factor model NEO N, E, O, and C and most cardiovascular traits showed evidence for genetic dominance. We found many SNPs enriched in specific loci, but could not prove their association because of only a moderate association with personality traits.
Beta-zero thalassemia in Sardinia is caused by a nonsense mutation. Author information Article notes Copyright and License information Disclaimer.
New York: Springer; Men normally have an X and a Y combination of sex chromosomes, while women have two X's. Finally, we examine evidence for an overlap in the genetic determinants of multiple traits, identifying clusters of traits that appear to be influenced by the same genes.